Code of Business Conduct and Ethics

The Board has adopted a Code of Business Conduct and Ethics that applies to all of our directors, officers (including our Chief Executive Officer, our Chief Financial Officer and our principal accounting officer) and employees.

Notice of Amendment:
On May 27, 2010, the Company's Board of Directors amended its Code of Business Conduct and Ethics to clarify the procedural steps an employee or director of OPKO must take when faced with a potential conflict of interest, requiring that an employee or director disclose a conflict of interest, or an appearance of a conflict of interest, to the Company's Compliance Officer, Legal Department, or Audit Committee for discussion, consultation and approval. In addition, language has been added that a determination by the Company that a conflict of interest is not harmful or improper, and its subsequent approval of such conflict in accordance with Company policy, will not be deemed a "waiver" of any provision of the Code of Business Conduct and Ethics. Finally, language was added to clarify that the Code is applicable to the Company's directors, employees, contractors and agents and to expand certain sections relating to anti-bribery and kickback laws.

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