Washington, D.C. 20549


Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB Number: 3235-0104
Estimated average burden
hours per response: 0.5
1. Name and Address of Reporting Person*
Fishel Robert Scott

(Last) (First) (Middle)

MIAMI FL 33137

(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
3. Issuer Name and Ticker or Trading Symbol
Opko Health, Inc. [ OPK ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Common Stock 4,001,428 I See Footnote(1)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
1. These securities are held by ALSAR Ltd. Partnership, of which Dr. Fishel is the President and CEO. The general partner of ALSAR Ltd. Partnership is SARAL Corporation. Dr. Fishel is the sole shareholder and the sole and exclusive beneficiary of SARAL Corporation.
Adam Logal, Attorney-In-Fact 04/04/2018
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

      KNOW ALL BY THESE PRESENTS, that the undersigned hereby constitutes and
appoints each of Adam Logal and Steven D. Rubin, each acting individually, as
the undersigned's true and lawful attorney in fact, with full power and
authority as hereinafter described on behalf of and in the name, place and stead
of the undersigned to:
(1) prepare, execute, acknowledge, deliver and file Forms 3, 4, and 5 (including
any amendments thereto) with respect to the securities of OPKO Health, Inc., a
Delaware corporation (the "Company"), with the United States Securities and
Exchange Commission, any national securities exchanges and the Company, as
considered necessary or advisable under Section 16 (a) of the Securities
Exchange Act of 1934 and the rules and regulations promulgated thereunder, as
amended from time to time (the "Exchange Act");

(2) seek or obtain, as the undersigned's representative and on the undersigned's
behalf, information on transactions in the Company's securities from any third
party, including brokers, employee benefit plan administrators and trustees, and
the undersigned hereby authorizes any such person to release any such
information to the  undersigned
 and approves and ratifies any such release of
information; and

(3) perform any and all other acts which in the discretion of such attorney in
fact are necessary or desirable for and on behalf of the undersigned in
connection with the foregoing.

The undersigned hereby acknowledges that:

(1) this Power of Attorney authorizes, but does not require, each such attorney
in fact to act in their discretion on information provided to such attorney in
fact without independent verification of such information;

(2) any documents prepared and/or executed by either such attorney in fact on
behalf of the undersigned pursuant to this Limited Power of Attorney will be in
such form and will contain such information and disclosure as such attorney in
fact, in his discretion, deems necessary or desirable;

(3) neither the Company nor either of such attorneys in fact assumes (i) any
liability for the undersigned's responsibility to comply with the requirements
of the Exchange Act, (ii) any liability of the undersigned for any failure to
comply with such requirements, or (iii) any obligation or liability of the
undersigned for profit disgorgement under Section 16 (b) of the Exchange Act;

(4) this Limited Power of Attorney does not relieve the undersigned from
responsibility for compliance with the undersigned's obligations under the
Exchange Act, including without limitation the reporting requirements under
Section 16 of the Exchange Act.

      The undersigned hereby gives and grants each of the foregoing attorneys in
fact full power and authority to do and perform all and every act and thing
whatsoever requisite, necessary or appropriate to be done in and about the
foregoing matters as fully to all intents and purposes as the undersigned might
or could do if present, hereby ratifying all that each such attorney in fact of,
for and on behalf of the undersigned, shall lawfully do or cause to be done by
virtue of this Limited Power of Attorney.
      This Limited Power of Attorney shall remain in full force and effect until
revoked by the undersigned in a signed writing delivered to each such attorney
in fact.
      IN WITNESS WHEREOF, the undersigned has caused this Limited Power of
Attorney to be executed this 22nd day of March, 2018.

/s/ Robert S. Fishel, M.D.	
Robert S. Fishel, M.D.


Before me personally appeared Robert S. Fishel, M.D., an individual personally
known to me (or satisfactorily proven) to be the person described in and who
executed the foregoing instrument, and acknowledged to and before me that he
executed said instrument for the purposes therein expressed. 

WITNESS my hand and official seal, this 22nd day of March, 2018.
/s/ Michelle Walczak	
(Signature of Notary)
Michelle Walczak	
(Printed Name of Notary) 
Notary Public in and for the State of Florida

My Commission Expires:

Notary Public State of Florida	
Commission # GG099186	
My Comm. Expires Apr 30, 2021
Bonded through National Notary Assn.
X	Personally Known OR
	Produced Identification
Type of Identification: